Biological and Medical Applications of Materials and Interfaces
- Aditya Yadav
Aditya Yadav
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati 45267, Ohio, United States
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- Zhou Fang
Zhou Fang
Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China
More by Zhou Fang
- Yuxin Wang
Yuxin Wang
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati 45267, Ohio, United States
The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati 45221, Ohio, United States
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- Kangqiang Qiu
Kangqiang Qiu
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati 45267, Ohio, United States
More by Kangqiang Qiu
- Adrian Tan
Adrian Tan
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati 45267, Ohio, United States
More by Adrian Tan
- Zihan Tang
Zihan Tang
Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China
- Xiang Zhang
Xiang Zhang
Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati 45267, Ohio, United States
More by Xiang Zhang
- Baohua Ji
Baohua Ji
Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China
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- Dechang Li*
Dechang Li
Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China
*Email: [emailprotected]
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- Jiajie Diao*
Jiajie Diao
Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati 45267, Ohio, United States
*Email: [emailprotected]
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.5c03796
Published April 20, 2025
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Abstract
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Carbon nanotubes (CNTs) have garnered significant attention in recent years due to their unique properties and their wide-range applicability. However, alongside these promising applications, concerns regarding the potential toxicity of CNTs have emerged. In this context, through this work, we have attempted to explore the nanotoxic effect of CNTs over endoplasmic reticular (ER). Using structure illumination and transmission electron microscopies, we unveiled that during endocytosis processes, CNTs form clusters, which lead to fragmentation of the ER structure by puncturing them, thereby inducing potential nanotoxicity. In addition, RNA sequencing data showed that after incubation with CNTs, activating transcription factor 4 (ATF4), a gene responsible for ER stress, was found to be up-regulated. To explore the molecular mechanism, we employed molecular dynamics and coarse-grained simulations and found that clustering of CNTs can significantly increase the speed of lipid extraction, resulting in severe damage.
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- Carbon nanotubes
- Extraction
- Genetics
- Lipids
- Membranes
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 20, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
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